Clinical Significance of Monocyte Chemoattractant Protein-1 and CC Chemokine Receptor Type 2 Gene Polymorphisms in Young Patients with Acute Coronary Syndrome
نویسندگان
چکیده
Amaç: Akut koroner sendrom (AKS), küresel ölümlerin birincil nedenidir. Genç nüfus arasında AKS'nin risk faktörlerini ve altta yatan nedenlerini belirleme konusunda özel bir endişe vardır. Genetik faktörler, günümüzde hastalık önleme erken teşhis açısından popüler çalışma konusu haline gelmiştir. Bu çalışmada genç akut sendromlu (GACS) hastalarda Monosit Kemoatraktan Protein-1(MCP-1) (A-2518G) C-C kemokin reseptör tip 2 (CCR2) (G190A) gen polimorfizmleri arasındaki klinik önemi araştırmayı amaçladık. Materyal metod: GACS'li (<40 yaş) 63 arterleri normal olan 103 hasta bu çalışmaya dahil edildi. Tüm MCP-1(A-2518G) CCR2(G190A) ölçüldü. Bulgular: MCP 1 polimorfizmi iki grupla karşılaştırıldığında önemli ölçüde farklıydı. GACS grupta MCP-1 geni GG (sırasıyla %12,7 ’e karşı %3,7), AG %33,3’e %50,5), AA %54’e %45,8), (p: 0.021) genotipleri ilişkinin yüksek olduğu gösterilmiştir. Sonuç: grubunda genotipinin riskini kat arttırdığı gösterildi.
منابع مشابه
Glycated LDL increases monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated chemotaxis.
BACKGROUND Previous reports have suggested that levels of advanced glycation end product-modified LDL (AGE-LDL) increase in patients with diabetes due to elevated plasma glucose. However, understanding of the mechanisms by which AGE-LDL may accelerate atherogenesis remains incomplete. METHODS AND RESULTS Microarray and reverse transcription real-time PCR (RT-PCR) analyses revealed that AGE-LD...
متن کاملSerum Levels of Monocyte Chemoattractant Protein-1 Correlate with Poor Clinical Grades in Cerebral Aneurysms
Background : Ruptured cerebral aneurysms (ICAs) are the most common non-traumatic cause of subarachnoid hemorrhage (SAH) that is associated with life threatening complications such as Vasospasm, Infarction, and Hydrocephalus (HCP). The active participation of macrophage/monocyte-mediated inflammatory response in the pathogenesis of cerebral aneurysm as labeled with Monocyte ChemoattractantProte...
متن کاملC-reactive protein promotes monocyte chemoattractant protein-1--mediated chemotaxis through upregulating CC chemokine receptor 2 expression in human monocytes.
BACKGROUND Inflammation plays a crucial role in atherosclerosis. An elevated serum C-reactive protein (CRP) level is a strong marker for future atherosclerotic cardiovascular diseases. In addition, recent data suggest that CRP may directly promote atherogenesis. In this study, we investigated whether CRP can directly activate human circulating monocytes. METHODS AND RESULTS Incubation of THP-...
متن کاملThe effect of monocyte chemoattractant protein-1/CC chemokine ligand 2 on aqueous humor outflow facility.
PURPOSE To investigate the effect of monocyte chemoattractant protein-1 (MCP-1)/CC chemokine ligand 2 on aqueous humor outflow facility. METHODS Aqueous humor outflow facility was measured in enucleated porcine eyes in a constant pressure perfusion system with or without MCP-1 (1600 ng/mL). Expression of CCR2, an MCP-1 receptor, in Schlemm's canal endothelial (SCE) cells was examined by rever...
متن کاملExpression of the chemokine monocyte chemoattractant protein-1 and its receptor chemokine receptor 2 in human crescentic glomerulonephritis.
Crescents are morphologic manifestations of severe glomerular injury. Several chemokines and their receptors have been demonstrated to be involved in animal models of crescentic glomerulonephritis (cGN) and are potential targets for therapeutic interventions. Therefore, the expression of monocyte chemoattractant protein-1 (MCP-1), its receptor chemokine receptor 2B (CCR2B), and CCR5 in human cG...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Harran Üniversitesi týp fakültesi dergisi
سال: 2022
ISSN: ['1304-9623', '1309-4025']
DOI: https://doi.org/10.35440/hutfd.1126015